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Cellular Biochemistry

Corsi di laurea:
Molecular Biology and Genetic
Docenti:
Minetti Giampaolo
Anno accademico:
2011/2012
Crediti formativi:
6
Ambiti:
BIO/10
Decreto Ministeriale:
270/04
Lingua di insegnamento:
Inglese

ModalitÓ

esame scritto o orale, da concordare con gli studenti

Prerequisiti

Methods in Biochemistry course in the first year

Programma

Protein synthesis
Selenoproteins
Protein structure
Protein folding and molecular chaperones
Protein turnover and degradation (ubiquitination etc)
Post-translational modifications of proteins (see specific modifications)
Membrane structure
The lipid bilayer
Membrane proteins
Post-translational protein modification : acylation
The red blood cell as a model membrane
Protein sorting and intracellular compartments
Intracellular vesicular traffic
Post-translational protein modification : glycosylation
Endocytosis, pinocytosis, Exocytosis, secretory vesicles
Phagocytosis, neutrophils and oxidative burst
Mechanisms of cell communication and signaling, general principles
Signaling through G-protein-coupled receptors
Signaling through enzyme-coupled receptors
Post-translational protein modification : phosphorylation
Signaling pathways dependent on proteolysis of gene regulatory proteins
Regulation of programmed cell-death (apoptosis)
Cancer

Bibliografia

Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P: Molecular Biology of the Cell. 5th ed. Garland Science, 2007.

Voet D, Voet JG: Biochemistry. Wiley, 2010.

Cooper GM, Hausman RE: The Cell: A Molecular Approach. Fifth Edition, Sinauer Associates Inc., 2009.

Branden C, Tooze J: Introduction to Protein Structure, Second Edition. Garland Science, 1999.


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Credits: apnetwork.it