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Cellular Biochemistry

Corsi di laurea:
Molecular Biology and Genetic
Docenti:
Minetti Giampaolo
Anno accademico:
2012/2013
Crediti formativi:
6
Ambiti:
BIO/10
Decreto Ministeriale:
509/99
Ore di lezione:
48
Lingua di insegnamento:
Inglese

ModalitÓ

Esame scritto e orale

Prerequisiti

Methods in Biochemistry course in the first year

Programma

Protein synthesis
Protein structure
Protein folding and molecular chaperones
Protein turnover and degradation (ubiquitination etc)
Post-translational modifications of proteins (see specific modifications)

Membrane structure
The lipid bilayer
Membrane proteins
Post-translational protein modification : acylation
The red blood cell as a model membrane

Protein sorting and intracellular compartments

Intracellular vesicular traffic
Post-translational protein modification : glycosylation
Endocytosis, pinocytosis, Exocytosis, secretory vesicles
Phagocytosis, neutrophils and oxidative burst

Mechanisms of cell communication
General principles
Signaling through G-protein-coupled receptors
Signaling through enzyme-coupled receptors
Post-translational protein modification : phosphorylation
Signaling pathways dependent on proteolysis of gene regulatory proteins

Cell cycle

Regulation of programmed cell-death (apoptosis)

Cancer

Bibliografia

Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P: Molecular Biology of the Cell. 5th ed. Garland Science, 2007.

Cooper GM, Hausman RE: The Cell: A Molecular Approach. Fifth Edition, Sinauer Associates Inc., 2009.

Branden C, Tooze J: Introduction to Protein Structure, Second Edition. Garland Science, 1999.


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Credits: apnetwork.it