UniversitÓ degli Studi di Pavia - FacoltÓ di Scienze MMFFNN

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Maga Giovanni

Qualifica:
Professore a contratto
Ricevimento:
Lunedý/Giovedý 14.30-16.30
E-mail:
maga (at) igm.cnr.it
Telefono:
0382546354
Fax:
0382422286
Sito web:
www.igm.cnr.it

Elenco corsi

2011/2012
Biologia molecolare II

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Curriculum

Breve Curriculum Vitae

Dr. Giovanni Maga

Istituto di Genetica Molecolare IGM-CNR, via Abbiategrasso 207, I-27100 Pavia (Italy)

Phone: +39-0382546354 (office); +39-0382546355 (lab)

Fax: +39-0382422286

e-mail: maga@igm.cnr.it

Web http://www.igm.cnr.it/

 

Formazione:

Laurea in Scienze Biologiche, UniversitÓ degli Studi di Pavia 1989

Master in Genetica, UniversitÓ degli Studi di Pavia 1990

Diploma di Specializzazione presso la Scuola di

Specializzazione in Genetica Applicata dell'UniversiÓ di Pavia 1993

Postdoctoral fellow all'Istituto di Biochimica e Biologia Molecolare

dell' UniversitÓ di Zurigo, Svizzera 1993–1996

Postdoctoral Fellow all' Istituto di Genetica Molecolare IGM-CNR

(con Fellowship ICGEB e ISS-AIDS) 1997-1999

Ricercatore a Contratto presso Istituto di Genetica Molecolare IGM-CNR 2000-2001

Ricercatore Confermato presso Istituto di Genetica Molecolare IGM-CNR 2001

Primo Ricercatore presso Istituto di Genetica Molecolare IGM-CNR 2005

Responsabile della Sezione Enzimologia del DNA & Virologia Molecolare

presso Istituto di Genetica Molecolare IGM-CNR 2006

 

Memberships/Editorial Activity

Editor del libro "DNA Replication Repair and Recombination"

Research Signpost, 2008 (ISBN 978-81-308-0253-4)

Autore del libro "DNA polymerases"

World Research Publ, 2010 (ISBN 978-981-4299-16-9)

Autore del libro "Occhio ai virus"

Chiavi di Lettura Zanichelli (ISBN 978-88-08-17380-5)

Guest Editor della rivista Current Drug Metabolism (ISSN 1389-2002)

Associate Editor della rivista American Journal of Biochemistry

and Biotechnology (ISSN 1553-3468)

Associate Editor della rivista  American Journal of

Infectious Deseases (ISSN 1553-6203)

Editorial Advisor della rivista The Biochemical Journal (ISSN 0264-6021)

Editorial Board Member della rivista The Open Biology Journal (ISSN 1874-1967)

Editorial Board Member of the Journal of Biological Chemistry (ISSN 0021-9258)

Academic Editor della rivista PLoS ONE (eISSN-1932-6203)

Membro della Biochemical Society (London)

Membro della American Society for Biochemistry and Molecular Biology

 

Pubblicazioni

Il Dr. Maga Ŕ autore/co-autore di 191 pubblicazioni su riviste internazionali ISI in lingua inglese (ISI WOS) e di oltre 80 comunicazioni a congressi nazionali e internazionali. Il suo H-index Ŕ 39 (Google Scholar).

 

 

Progetti di ricerca

AttivitÓ scientifica

Il Dr. Maga si Ŕ sempre interessato allo studio della enzimologia della replicazione e riparazione del DNA in cellule animali e in virus. La sua ricerca in questi anni si Ŕ focalizzata sulle seguenti linee di ricerca:

1.     Enzimologia della replicazione del DNA

2.     Nuove strategie antivirali contro le infezioni da HCV/HIV

3.     Farmaco resistenza del virus HIV

        4.  Nuovi bersagli per la terapia antitumorale

 

Pubblicazioni

1. La Regina G, Coluccia A, Brancale A, Piscitelli F, Famiglini V, Cosconati S, Maga G, Samuele A, Gonzalez E, Clotet B, Schols D, EstÚ JA, Novellino E, Silvestri R. New Nitrogen Containing Substituents at the Indole-2-carboxamide Yield High Potent and Broad Spectrum Indolylarylsulfone HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. J Med Chem. 2012 Jul 26;55(14):6634-8.

2.Samuele A, Crespan E, Garbelli A, Bavagnoli L, Maga G. The power of enzyme kinetics in the drug development process. Curr Pharm Biotechnol. 2012 Mar 20. [Epub ahead of print]

3. Maga G. New targets and new drugs: from in silico planning to in vivo testing. Curr Pharm Biotechnol. 2012 Mar 20. [Epub ahead of print]

4. Rotili D, Samuele A, Tarantino D, Ragno R, Musmuca I, Ballante F, Botta G, Morera L, Pierini M, Cirilli R, Nawrozkij MB, Gonzalez E, Clotet B, Artico M, EstÚ JA, Maga G, Mai A. 2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies. J Med Chem. 2012 Apr 12;55(7):3558-62.

5.Radi M, Pagano M, Franchi L, Castagnolo D, Schenone S, Casaluce G, Zamperini C, Dreassi E, Maga G, Samuele A, Gonzalo E, Clotet B, EstÚ JA, Botta M. Synthesis, biological activity, and ADME properties of novel S-DABOs/N-DABOs as HIV reverse transcriptase inhibitors. ChemMedChem. 2012 May;7(5):883-96.

6. Crespan E, Czabany T, Maga G, HŘbscher U. Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases λ and β on normal and repetitive DNA sequences. Nucleic Acids Res. 2012 Jul;40(12):5577-90

7.Radi M, Falchi F, Garbelli A, Samuele A, Bernardo V, Paolucci S, Baldanti F, Schenone S, Manetti F, Maga G, Botta M. Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: mtowards the next generation HIV-1 inhibitors. Bioorg Med Chem Lett. 2012 Mar 1;22(5):2094-8.

8.Manfroni G, Meschini F, Barreca ML, Leyssen P, Samuele A, Iraci N, Sabatini S, Massari S, Maga G, Neyts J, Cecchetti V. Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase. Bioorg Med Chem. 2012 Jan 15;20(2):866-76.

9.Crespan E, Maga G, HŘbscher U. A new proofreading mechanism for lesion bypass  by DNA polymerase-λ. EMBO Rep. 2011 Dec 23;13(1):68-74.

10.         Bavagnoli L, Dundon WG, Garbelli A, Zecchin B, Milani A, Parakkal G, Baldanti F, Paolucci S, Volmer R, Tu Y, Wu C, Capua I, Maga G. The PDZ-Ligand and Src-Homology Type 3 Domains of Epidemic Avian Influenza Virus NS1 Protein Modulate Human Src Kinase Activity during Viral Infection. PLoS One. 2011;6(11):e27789.

11.        Samuele A, Bisi S, Kataropoulou A, La Regina G, Piscitelli F, Gatti V, Silvestri R, Maga G. Mechanism of interaction of novel indolylarylsulfone derivatives with K103N and Y181I mutant HIV-1 reverse transcriptase in complex with its substrates. Antivir Chem Chemother. 2011 Nov 17;22(3):107-18.

12.         Bavagnoli L, Maga G. The 2009 influenza pandemic: promising lessons for antiviral therapy for future outbreaks. Curr Med Chem. 2011 Dec 1;18(35):5466-75.

13.        Arioli F, Borrelli S, Colombo F, Falchi F, Filippi I, Crespan E, Naldini A,Scalia G, Silvani A, Maga G, Carraro F, Botta M, Passarella D. N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a scaffold for thesynthesis of inhibitors of Bcr-Abl. ChemMedChem. 2011 Nov 4;6(11):2009-18.

14.        Crespan E, Garbelli A, Amoroso A, Maga G. Exploiting the nucleotide substrate specificity of repair DNA polymerases to develop novel anticancer agents. Molecules. 2011 Sep 16;16(9):7994-8019.

15.         HŘbscher U, Maga G. DNA replication and repair bypass machines. Curr Opin Chem Biol. 2011 Oct;15(5):627-35.

16.        Radi M, Brullo C, Crespan E, Tintori C, Musumeci F, Biava M, Schenone S, Dreassi E, Zamperini C, Maga G, Pagano D, Angelucci A, Bologna M, Botta M. Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells. Bioorg Med Chem Lett. 2011 Oct 1;21(19):

17.          Maga G, Falchi F, Radi M, Botta L, Casaluce G, Bernardini M, Irannejad H, Manetti F, Garbelli A, Samuele A, Zanoli S, EstÚ JA, Gonzalez E, Zucca E, Paolucci S, Baldanti F, De Rijck J, Debyser Z, Botta M. Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation. ChemMedChem. 2011 Aug 1;6(8):1371-89. 21698775.

18.        Crespan E, Zucca E, Maga G. Overcoming the drug resistance problem with second-generation tyrosine kinase inhibitors: from enzymology to structural models. Curr Med Chem. 2011;18(19):2836-47.

19.        Garbelli A, Radi M, Falchi F, Beermann S, Zanoli S, Manetti F, Dietrich U, Botta M, Maga G. Targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase as a novel strategy to inhibit viral replication. Curr Med Chem. 2011;18(20):3015-27.

20.         Butini S, Gemma S, Brindisi M, Borrelli G, Fiorini I, Samuele A, Karytinos A, Facchini M, Lossani A, Zanoli S, Campiani G, Novellino E, Focher F, Maga G. Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants. Bioorg Med Chem Lett. 2011 Jul 1;21(13):3935-8.

21.        Garbelli A, Beermann S, Di Cicco G, Dietrich U, Maga G. A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replication. PLoS One. 2011 May 12;6(5):e19810.

22.         Radi M, Dreassi E, Brullo C, Crespan E, Tintori C, Bernardo V, Valoti M, Zamperini C, Daigl H, Musumeci F, Carraro F, Naldini A, Filippi I, Maga G, Schenone S, Botta M. Design, synthesis, biological activity, and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study. J Med Chem. 2011 Apr 28;54(8):2610-26.

23.        Rotili, D., Tarantino, D., Artico, M., Nawrozkij, M.B., Gonzalez-Ortega, E., Clotet, B., Samuele, A., Este, J.A., Maga, G. and Mai, A. (2011) Diarylpyrimidine-Dihydrobenzyloxopyrimidine Hybrids: New, Wide-Spectrum Anti-HIV-1 Agents Active at (Sub)-Nanomolar Level. J Med Chem 54(8), 3091-3096.

24.        Radi, M., Dreassi, E., Brullo, C., Crespan, E., Tintori, C., Bernardo, V., Valoti, M., Zamperini, C., Daigl, H., Musumeci, F., Carraro, F., Naldini, A., Filippi, I., Maga, G., Schenone, S. and Botta, M. (2011) Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study. J Med Chem 54(8), 2610-26.

25.        Peduto, A., Massa, A., Di Mola, A., de Caprariis, P., La Colla, P., Loddo, R., Altamura, S., Maga, G. and Filosa, R. (2011) 2,3-Dihydro-1,2-Diphenyl-substituted 4H-Pyridinone Derivatives as New Anti Flaviviridae Inhibitors. Chem Biol Drug Des.

26.        La Regina, G., Coluccia, A., Brancale, A., Piscitelli, F., Gatti, V., Maga, G., Samuele, A., Pannecouque, C., Schols, D., Balzarini, J., Novellino, E. and Silvestri, R. (2011) Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide. J Med Chem 54(6), 1587-98.

27.        Gemma, S., Butini, S., Campiani, G., Brindisi, M., Zanoli, S., Romano, M.P., Tripaldi, P., Savini, L., Fiorini, I., Borrelli, G., Novellino, E. and Maga, G. (2011) Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase. Bioorg Med Chem Lett 21(9), 2776-9.

28.        Butini, S., Gemma, S., Brindisi, M., Borrelli, G., Lossani, A., Ponte, A.M., Torti, A., Maga, G., Marinelli, L., La Pietra, V., Fiorini, I., Lamponi, S., Campiani, G., Zisterer, D.M., Nathwani, S.M., Sartini, S., La Motta, C., Da Settimo, F., Novellino, E. and Focher, F. (2011) Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies. J Med Chem 54(5), 1401-20.

29.        Amoroso, A., Concia, L., Maggio, C., Raynaud, C., Bergounioux, C., Crespan, E., Cella, R. and Maga, G. (2011) Oxidative DNA Damage Bypass in Arabidopsis thaliana Requires DNA Polymerase {lambda} and Proliferating Cell Nuclear Antigen 2. Plant Cell 23(2), 806-22.

30.        Samuele, A., Crespan, E., Vitellaro, S., Monforte, A., Logoteta, P., Chimirri, A. and Maga, G. (2010) Slow binding-tight binding interaction between benzimidazol-2-one inhibitors and HIV-1 reverse transcriptase containing the lysine 103 to asparagine mutation. Antiviral Research 86(3), 268-275.

31.        Radi, M., Crespan, E., Falchi, F., Bernardo, V., Zanoli, S., Manetti, F., Schenone, S., Maga, G. and Botta, M. (2010) Design and Synthesis of Thiadiazoles and Thiazoles Targeting the Bcr-Abl T315I Mutant: from Docking False Positives to ATP-Noncompetitive Inhibitors. Chemmedchem 5(8), 1226-1231.

32.        Pitta, E., Crespan, E., Geronikaki, A., Maga, G. and Samuele, A. (2010) Novel Thiazolidinone Derivatives with an Uncommon Mechanism of Inhibition Towards HIV-1 Reverse Transcriptase. Letters in Drug Design & Discovery 7(4), 228-234.

33.        Murugesan, S., Ganguly, S. and Maga, G. (2010) Synthesis, evaluation and molecular modelling studies of some novel 3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(substituted-phenyl)propanamides as HIV-1 non-nucleoside reverse transcriptase inhibitors. Journal of Chemical Sciences 122(2), 169-176.

34.        Monforte, A., Logoteta, P., De Luca, L., Iraci, N., Ferro, S., Maga, G., De Clercq, E., Pannecouque, C. and Chimirri, A. (2010) Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry 18(4), 1702-1710.

35.        Maga, G., Radi, M., Gerard, M., Botta, M. and Ennifar, E. (2010) HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate. Viruses-Basel 2(4), 880-899.

36.        Maga, G., Falchi, F., Garbelli, A., Radi, M., Paolucci, S., Baldanti, F. and Botta, M. (2010) Inhibitors of human immunodeficiency virus-1 replication targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase. Retrovirology 7, 15-15.

37.        Kruewel, T., Schenone, S., Radi, M., Maga, G., Rohrbeck, A., Botta, M. and Borlak, J. (2010) Molecular Characterization of c-Abl/c-Src Kinase Inhibitors Targeted against Murine Tumour Progenitor Cells that Express Stem Cell Markers. Plos One 5(11).

38.        Gemma, S., Butini, S., Campiani, G., Brindisi, M., Zanoli, S., Romano, M.P., Tripaldi, P., Savini, L., Fiorini, I., Borrelli, G., Novellino, E. and Maga, G. (2010) Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase. Bioorg Med Chem Lett 21(9), 2776-9.

39.        Freisz, S., Bec, G., Radi, M., Wolff, P., Crespan, E., Angeli, L., Dumas, P., Maga, G., Botta, M. and Ennifar, E. (2010) Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action. Angewandte Chemie-International Edition 49(10), 1805-1808.

40.        Crespan, E., Amoroso, A. and Maga, G. (2010) DNA polymerases and mutagenesis in human cancers. Subcell Biochem 50, 165-88.

41.        Crespan, E., Radi, M., Zanoli, S., Schenone, S., Botta, M. and Maga, G. (2010) Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms. Bioorganic & Medicinal Chemistry 18(11), 3999-4008.

42.        Campanini, G., Piralla, A., Paolucci, S., Rovida, F., Percivalle, E., Maga, G. and Baldanti, F. (2010) Genetic divergence of influenza A NS1 gene in pandemic 2009 H1N1 isolates with respect to H1N1 and H3N2 isolates from previous seasonal epidemics. Virology Journal 7.

43.        Belousova, E., Maga, G., Fan, Y., Kubareva, E., Romanova, E., Lebedeva, N., Oretskaya, T. and Lavrik, O. (2010) DNA Polymerases beta and lambda Bypass Thymine Glycol in Gapped DNA Structures. Biochemistry 49(22), 4695-4704.

44.        Savio, M., Coppa, T., Bianchi, L., Vannini, V., Maga, G., Forti, L., Cazzalini, O., Lazze, M., Perucca, P., Prosperi, E. and Stivala, L. (2009) The resveratrol analogue 4,4 '-dihydroxy-trans-stilbene inhibits cell proliferation with higher efficiency but different mechanism from resveratrol. International Journal of Biochemistry & Cell Biology 41(12), 2493-2502.

45.        SAMUELE, A., KATAROPOULOU, A., VIOLA, M., ZANOLI, S., LA REGINA, G., PISCITELLI, F., SILVESTRI, R. and MAGA, G. (2009) Non-nucleoside HIV-1 reverse transcriptase inhibitors di-halo-indolyl aryl sulfones achieve tight binding to drug-resistant mutants by targeting the enzyme-substrate complex. ANTIVIRAL RESEARCH 81(1), 47-55.

46.        RADI, M., MAGA, G., ALONGI, M., ANGELI, L., SAMUELE, A., ZANOLI, S., BELLUCCI, L., TAFI, A., CASALUCE, G., GIORGI, G., ARMAND-UGON, M., GONZALEZ, E., ESTE, J., BALTZINGER, M., BEC, G., DUMAS, P., ENNIFAR, E. and BOTTA, M. (2009) Discovery of Chiral Cyclopropyl Dihydro-Alkylthio-Benzyl-Oxopyrimidine (S-DABO) Derivatives as Potent HIV-1 Reverse Transcriptase Inhibitors with High Activity Against Clinically Relevant Mutants. JOURNAL OF MEDICINAL CHEMISTRY 52(3), 840-851.

47.        PISCITELLI, F., COLUCCIA, A., BRANCALE, A., LA REGINA, G., SANSONE, A., GIORDANO, C., BALZARINI, J., MAGA, G., ZANOLI, S., SAMUELE, A., CIRILLI, R., LA TORRE, F., LAVECCHIA, A., NOVELLINO, E. and SILVESTRI, R. (2009) Indolylarylsulfones Bearing Natural and Unnatural Amino Acids. Discovery of Potent Inhibitors of HIV-1 Non-Nucleoside Wild Type and Resistant Mutant Strains Reverse Transcriptase and Coxsackie B4 Virus. JOURNAL OF MEDICINAL CHEMISTRY 52(7), 1922-1934.

48.        OLLA, S., MANETTI, F., CRESPAN, E., MAGA, G., ANGELUCCI, A., SCHENONE, S., BOLOGNA, M. and BOTTA, M. (2009) Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19(5), 1512-1516.

49.        MONFORTE, A., LOGOTETA, P., FERRO, S., DE LUCA, L., IRACI, N., MAGA, G., DE CLERCQ, E., PANNECOUQUE, C. and CHIMIRRI, A. (2009) Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents. BIOORGANIC & MEDICINAL CHEMISTRY 17(16), 5962-5967.

50.        MANFRONI, G., PAESHUYSE, J., MASSARI, S., ZANOLI, S., GATTO, B., MAGA, G., TABARRINI, O., CECCHETTI, V., FRAVOLINI, A. and NEYTS, J. (2009) Inhibition of Subgenomic Hepatitis C Virus RNA Replication by Acridone Derivatives: Identification of an NS3 Helicase Inhibitor. JOURNAL OF MEDICINAL CHEMISTRY 52(10), 3354-3365.

51.        MAGA, G., VAN LOON, B., CRESPAN, E., VILLANI, G. and HUBSCHER, U. (2009) The Block of DNA Polymerase delta Strand Displacement Activity by an Abasic Site Can Be Rescued by the Concerted Action of DNA Polymerase beta and Flap Endonuclease 1. JOURNAL OF BIOLOGICAL CHEMISTRY 284(21), 14267-14275.

52.        KATAROPOULOU, A., BOVOLENTA, C., BELFIORE, A., TRABATTI, S., GARBELLI, A., PORCELLINI, S., LUPO, R. and MAGA, G. (2009) Mutational analysis of the HIV-1 auxiliary protein Vif identifies independent domains important for the physical and functional interaction with HIV-1 reverse transcriptase. NUCLEIC ACIDS RESEARCH 37(11), 3660-3669.

53.        Hubscher, U. and Maga, G. (2009) Repair DNA polymerases as anticancer drug targets. Ejc Supplements 7(2), 39-40.

54.        GANGULY, S., MURUGESAN, S. and MAGA, G. (2009) SYNTHESIS, EVALUATION AND MOLECULAR MODELING STUDIES OF SOME NOVEL TETRAHYDROISOQUINOLINE DERIVATIVES TARGETED AT THE HIV-1 REVERSE TRANSCRIPTASE. INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 18(4), 357-360.

55.        FALCHI, F., MANETTI, F., CARRARO, F., NALDINI, A., MAGA, G., CRESPAN, E., SCHENONE, S., BRUNO, O., BRULLO, C. and BOTTA, M. (2009) 3D QSAR Models Built on Structure-Based Alignments of Abl Tyrosine Kinase Inhibitors. CHEMMEDCHEM 4(6), 976-987.

56.        DREASSI, E., ZIZZARI, A., FALCHI, F., SCHENONE, S., SANTUCCI, A., MAGA, G. and BOTTA, M. (2009) Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 44(9), 3712-3717.

57.        CHIMIRRI, A., DE CLERCQ, E., MAGA, G., LOGOTETA, P., FERRO, S., DE LUCA, L., IRACI, N., PANNECOUQUE, C. and MONFORTE, A. (2009) Design, Synthesis and SAR of New Potent HIV-1 RT Inhibitors. Antiviral Research. Vol. 82, A56-A57.

58.        BUTINI, S., BRINDISI, M., COSCONATI, S., MARINELLI, L., BORRELLI, G., COCCONE, S., RAMUNNO, A., CAMPIANI, G., NOVELLINO, E., ZANOLI, S., SAMUELE, A., GIORGI, G., BERGAMINI, A., DI MATTIA, M., LALLI, S., GALLETTI, B., GEMMA, S. and MAGA, G. (2009) Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations. JOURNAL OF MEDICINAL CHEMISTRY 52(4), 1224-1228.

59.        ZANOLI, S., GEMMA, S., BUTINI, S., BRINDISI, M., JOSHI, B., CAMPIANI, G., FATTORUSSO, C., PERSICO, M., CRESPAN, E., CANCIO, R., SPADARIA, S., HUBSCHER, U. and MAGA, G. (2008) Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the "primer grip" region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants. BIOCHEMICAL PHARMACOLOGY 76(2), 156-168.

60.        SHARMA, B., CRESPAN, E., VILLANI, G. and MAGA, G. (2008) The balance between the rates of incorporation and pyrophosphorolytic removal influences the HIV-1 reverse transcriptase bypass of an abasic site with deoxy-, dideoxy-, and ribonucleotides. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 71(2), 715-727.

61.        SCHENONE, S., BRULLO, C., BRUNO, O., BONDAVALLI, F., MOSTI, L., MAGA, G., CRESPAN, E., CARRARO, F., MANETTI, F., TINTORI, C. and BOTTA, M. (2008) Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 43(12), 2665-2676.

62.        SAMUELE, A., FACCHINI, M., ROTILI, D., MAI, A., ARTICO, M., ARMAND-UGON, M., ESTE, J. and MAGA, G. (2008) Substrate-induced stable enzyme-inhibitor complex formation allows tight binding of novel 2-aminopyrimidin-4(3H)-ones to drug-resistant HIV-1 reverse transcriptase mutants. CHEMMEDCHEM 3(9), 1412-1418.

63.        RADI, M., FALCIANI, C., CONTEMORI, L., PETRICCI, E., MAGA, G., SAMUELE, A., ZANOLI, S., TERRAZAS, M., CASTRIA, M., TOGNINELLI, A., ESTE, J., CLOTET-CODINA, I., ARMAND-UGON, M. and BOTTA, M. (2008) A multidisciplinary approach for the identification of novel HIV-1 non-nucleoside reverse transcriptase inhibitors: S-DABOCs and DAVPs. Austrian/German/Hungarian/Italian/Polish/Slovenian Joint Meeting on Medicinal Chemistry. Vol. 3, 573-593.

64.        RADI, M., CRESPAN, E., BOTTA, G., FALCHI, F., MAGA, G., MANETTI, F., CORRADI, V., MANCINI, M., SANTUCCI, M., SCHENONE, S. and BOTTA, M. (2008) Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 18(3), 1207-1211.

65.        RADI, M., ANGELI, L., FRANCHI, L., CONTEMORI, L., MAGA, G., SAMUELE, A., ZANOLI, S., ARMAND-UGON, M., GONZALEZ, E., LLANO, A., ESTE, J. and BOTTA, M. (2008) Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 18(21), 5777-5780.

66.        NAWROZKIJ, M., ROTILI, D., TARANTINO, D., BOTTA, G., EREMIYCHUK, A., MUSMUCA, I., RAGNO, R., SAMUELE, A., ZANOLI, S., ARMAND-UGON, M., CLOTET-CODINA, I., NOVAKOV, I., ORLINSON, B., MAGA, G., ESTE, J., ARTICO, M. and MAI, A. (2008) 5-alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile. JOURNAL OF MEDICINAL CHEMISTRY 51(15), 4641-4652.

67.        MONFORTE, A., RAO, A., LOGOTETA, P., FERRO, S., DE LUCA, L., BARRECA, M., IRACI, N., MAGA, G., DE CLERCQ, E., PANNECOUQUE, C. and CHIMIRRI, A. (2008) Novel N-1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY 16(15), 7429-7435.

68.        MANETTI, F., FALCHI, F., CRESPAN, E., SCHENONE, S., MAGA, G. and BOTTA, M. (2008) N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 18(15), 4328-4331.

69.        MANETTI, F., BRULLO, C., MAGNANI, M., MOSCI, F., CHELLI, B., CRESPAN, E., SCHENONE, S., NALDINI, A., BRUNO, O., TRINCAVELLI, M., MAGA, G., CARRARO, F., MARTINI, C., BONDAVALLI, F. and BOTTAT, M. (2008) Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines. JOURNAL OF MEDICINAL CHEMISTRY 51(5), 1252-1259.

70.        MAGA, G. and HUBSCHER, U. (2008) Repair and translesion DNA polymerases as anticancer drug targets. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY 8(4), 431-447.

71.        MAGA, G., FALCHI, F., GARBELLI, A., BCFFIORE, A., WITVROUW, M., MANETTI, F. and BOTTA, M. (2008) Pharmacophore Modeling and Molecular Docking Led to the Discovery of Inhibitors of Human Immunodeficiency Virus-1 Replication Targeting the Human Cellular Aspartic Acid-Glutamic Acid-Alanine-Aspartic Acid Box Polypeptide 3. JOURNAL OF MEDICINAL CHEMISTRY 51(21), 6635-6638.

72.        MAGA, G., CRESPAN, E., WIMMER, U., VAN LOON, B., AMOROSO, A., MONDELLO, C., BELGIOVINE, C., FERRARI, E., LOCATELLI, G., VILLANI, G. and HUBSCHER, U. (2008) Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105(52), 20689-20694.

73.        LEMAY, J., MAIDOU-PEINDARA, P., CANCIO, R., ENNIFAR, E., COADOU, G., MAGA, G., RAIN, J., BENAROUS, R. and LIU, L. (2008) AKAP149 Binds to HIV-1 Reverse Transcriptase and Is Involved in the Reverse Transcription. JOURNAL OF MOLECULAR BIOLOGY 383(4), 783-796.

74.        BELOUSOVA, E., CRESPAN, E., LEBEDEVA, N., RECHKUNOVA, N., HUEBSCHER, U., MAGA, G. and LAVRIK, O. (2008) Photoreactive DNA probes as a tool for studying the translesion synthesis system in mammalian cell extracts. MEDICINAL CHEMISTRY 4(2), 155-162.

75.        THOMAS, M., MAGA, G., MOUSCADET, J. and HOWARTH, N. (2007) Investigation of novel lipid-functionalized PNA monomers as potential HIV-1 non-nucleoside reverse transcriptase and/or integrase inhibitors. Proceedings of the 17th International Roundtable of Nucleosides, Nucleotides, and Nucleic Acids. Vol. 26, 1063-1066.

76.        PARLANTI, E., LOCATELLI, G., MAGA, G. and DOGLIOTTI, E. (2007) Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins. NUCLEIC ACIDS RESEARCH 35(5), 1569-1577.

77.        PAOLUCCI, S., BALDANTI, F., CAMPANINI, G., CANCIO, R., BELFIORE, A., MAGA, G. and GERNA, G. (2007) NNRTI-selected mutations at codon 190 of human immunodeficiency virus type 1 reverse transcriptase decrease susceptibility to stavudine and zidovudine. ANTIVIRAL RESEARCH 76, 99-103.

78.        MUGNAINI, C., ALONGI, M., TOGNINELLI, A., GEVARIYA, H., BRIZZI, A., MANETTI, F., BERNARDINI, C., ANGELI, L., TAFI, A., BELLUCCI, L., CORELLI, F., MASSA, S., MAGA, G., SAMUELE, A., FACCHIM, M., CLOTET-CODINA, I., ARMAND-UGON, M., ESTE, J. and BOTTA, M. (2007) Dihydro-alkylthio-benzyl-oxopyrimidines as inhibitors of reverse transcriptase: Synthesis and rationalization of the biological data on both wild-type enzyme and relevant clinical mutants. JOURNAL OF MEDICINAL CHEMISTRY 50(26), 6580-6595.

79.        MANETTI, F., SANTUCCI, A., LOCATELLI, G., MAGA, G., SPREAFICO, A., SERCHI, T., ORLANDINI, M., BERNARDINI, G., CARADONNA, N., SPALLAROSSA, A., BRULLO, C., SCHENONE, S., BRUNO, O., RANISE, A., BONDAVALLI, F., HOFFMANN, O., BOLOGNA, M., ANGELUCCI, A. and BOTTA, M. (2007) Identification of a novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice. JOURNAL OF MEDICINAL CHEMISTRY 50, 5579-5588.

80.        MANETTI, F., PUCCI, A., MAGNANI, M., LOCATELLI, G., BRULLO, C., NALDINI, A., SCHENONE, S., MAGA, G., CARRARO, F. and BOTTA, M. (2007) Inhibition of Bcr-Abl phosphorylation and induction of apoptosis by pyrazolo[3,4-d]pyrimidines in human leukemia cells. CHEMMEDCHEM 2(3), 343-353.

81.        MAI, A., ARTICO, M., ROTILI, D., TARANTINO, D., CLOTET-CODINA, I., ARMAND-UGOON, M., RAGNO, R., SIMEONI, S., SBARDELLA, G., NAWROZKIJ, M., SAMUELE, A., MAGA, G. and ESTEE, J. (2007) Synthesis and biological properties of novel 2-Aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains. JOURNAL OF MEDICINAL CHEMISTRY 50, 5412-5424.

82.        MAGA, G., VILLANI, G., CRESPAN, E., WIMMER, U., FERRARI, E., BERTOCCI, B. and HUBSCHER, U. (2007) 8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins. NATURE 447(7144), 606-+.

83.        MAGA, G., RADI, M., ZANOLI, S., MANETTI, F., CANCIO, R., HUBSCHER, U., SPADARI, S., FALCIANI, C., TERRAZAS, M., VILARRASA, J. and BOTTA, M. (2007) Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 46(11), 1810-1813.

84.        LA REGINA, G., COLUCCIA, A., PISCITELLI, F., BERGAMINI, A., SINISTRO, A., CAVAZZA, A., MAGA, G., SAMUELE, A., ZANOLI, S., NOVELLINO, E., ARTICO, M. and SILVESTRI, R. (2007) Indolyl aryl Sulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: Role of two halogen atoms at the indole ring in developing new analogues with improved antiviral activity. JOURNAL OF MEDICINAL CHEMISTRY 50, 5034-5038.

85.        FRANCA, R., BELFIORE, A., SPADARI, S. and MAGA, G. (2007) Human DEAD-Box ATPase DDX3 shows a relaxed nucleoside substrate specificity. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 67(4), 1128-1137.

86.        CRESPAN, E., HUBSCHER, U. and MAGA, G. (2007) Error-free bypass of 2-hydroxyadenine by human DNA polymerase lambda with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts. NUCLEIC ACIDS RESEARCH 35, 5173-5181.

87.        CRESPAN, E., ALEXANDROVA, L., KHANDAZHINSKAYA, A., JASKO, M., KUKHANOVA, M., VILLANI, G., HUBSCHER, U., SPADARI, S. and MAGA, G. (2007) Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases beta and lambda. NUCLEIC ACIDS RESEARCH 35(1), 45-57.

88.        BARRECA, M., RAO, A., DE LUCA, L., IRACI, N., MONFORTE, A., MAGA, G. and DE CLERCQ, E. (2007) Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17(7), 1956-1960.

89.        BARRECA, M., DE LUCA, L., IRACI, N., RAO, A., FERRO, S., MAGA, G. and CHIMIRRI, A. (2007) Structure-based pharmacophore identification of new chemical scaffolds as non-nucleoside reverse transcriptase inhibitors. JOURNAL OF CHEMICAL INFORMATION AND MODELING 47(2), 557-562.

90.        BARONE, F., MCCULLOCH, S., MACPHERSON, P., MAGA, G., YAMADA, M., NOHMI, T., MINOPRIO, A., MAZZEI, F., KUNKEL, T., KARRAN, P. and BIGNAMI, M. (2007) Replication of 2-hydroxyadenine-containing DNA and recognition by human MutS alpha. DNA REPAIR 6(3), 355-366.

91.        ADEBAMBO, K., ZANOLI, S., THOMAS, M., CANCIO, R., HOWARTH, N. and MAGA, G. (2007) N-2-Benzyloxycarbonylguan-9-yl acetic acid derivatives as HIV-1 reverse transcriptase non-nucleoside inhibitors with decreased loss of potency against common drug-resistance mutations.. CHEMMEDCHEM 2, 1405-1409.

92.        SILVESTRI, R. and MAGA, G. (2006) Current state-of-the-art in preclinical and clinical development of novel non-nucleoside HIV-1 reverse transcriptase inhibitors. EXPERT OPINION ON THERAPEUTIC PATENTS 16(7), 939-962.

93.        RAGNO, R., COLUCCIA, A., LA REGINA, G., DE MARTINO, G., PISCITELLI, F., LAVECCHIA, A., NOVELLINO, E., BERGAMINI, A., CIAPRINI, C., SINISTRO, A., MAGA, G., CRESPAN, E., ARTICO, M. and SILVESTRI, R. (2006) Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide. JOURNAL OF MEDICINAL CHEMISTRY 49(11), 3172-3184.

94.        MUGNAINI, C., MANETTI, F., ESTE, J., CLOTET-CODINA, I., MAGA, G., CANCIO, R., BOTTA, M. and CORELLI, F. (2006) Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 16(13), 3541-3544.

95.        MANETTI, F., LOCATELLI, G., MAGA, G., SCHENONE, S., MODUGNO, M., FORLI, S., CORELLI, F. and BOTTA, M. (2006) A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. JOURNAL OF MEDICINAL CHEMISTRY 49(11), 3278-3286.

96.        MAGA, G., SHEVELEV, I., VILLANI, G., SPADARI, S. and HUBSCHER, U. (2006) Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase lambda. NUCLEIC ACIDS RESEARCH 34(5), 1405-1415.

97.        LAVECCHIA, A., COSTI, R., ARTICO, M., MIELE, G., NOVELLINO, E., BERGAMINI, A., CRESPAN, E., MAGA, G. and DI SANTO, R. (2006) Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: Synthesis, structure-activity relationships, and docking studies (Part 2). CHEMMEDCHEM 1(12), 1379-1390.

98.        FRANCA, R., SPADARI, S. and MAGA, G. (2006) APOBEC deaminases as cellular antiviral factors: A novel natural host defense mechanism. MEDICAL SCIENCE MONITOR 12(5), RA92-RA98.

99.        DI SANTO, R. and MAGA, G. (2006) Human terminal deoxynucleotidyl transferases as novel targets for anticancer chemotherapy. CURRENT MEDICINAL CHEMISTRY 13(20), 2353-2368.

100.    DI SANTO, R., COSTI, R., ARTICO, M., RAGNO, R., LAVECCHIA, A., NOVELLINO, E., GAVUZZO, E., LA TORRE, F., CIRILLI, R., CANCIO, R. and MAGA, G. (2006) Design, synthesis, biological evaluation, and molecular modeling studies of TIBO-like cyclic sulfones as non-nucleoside HIV-1 reverse transcriptase inhibitors. CHEMMEDCHEM 1(1), 82-95.

101.    DI SANTO, R., COSTI, R., ARTICO, M., MIELE, G., LAVECCHIA, A., NOVELLINO, E., BERGAMINI, A., CANCIO, R. and MAGA, G. (2006) Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: Synthesis, structure-activity relationships, and docking studies (Part 1). CHEMMEDCHEM 1(12), 1367-1378.

102.    CARRARO, F., NALDINI, A., PUCCI, A., LOCATELLI, G., MAGA, G., SCHENONE, S., BRUNO, O., RANISE, A., BONDAVALLI, F., BRULLO, C., FOSSA, P., MENOZZI, G., MOSTI, L., MODUGNO, M., TINTORI, C., MANETTI, F. and BOTTA, M. (2006) Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation. JOURNAL OF MEDICINAL CHEMISTRY 49(5), 1549-1561.

103.    RADI, M., PETRICCI, E., MAGA, G., CORELLI, F. and BOTTA, M. (2005) Parallel solution-phase synthesis of 4-dialkylamino-2-methylsulfonyl-6-vinylpyrimidines. JOURNAL OF COMBINATORIAL CHEMISTRY 7(1), 117-122.

104.    MICCOLI, L., FROUIN, I., NOVAC, O., DI PAOLA, D., HARPER, F., ZANNIS-HADJOPOULOS, M., MAGA, G., BIARD, D. and ANGULO, J. (2005) The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins. MOLECULAR AND CELLULAR BIOLOGY 25(9), 3814-3830.

105.    MANETTI, F., ESTE, J., CLOTET-CODINA, I., ARMAND-UGON, M., MAGA, G., CRESPAN, E., CANCIO, R., MUGNAINI, C., BERNARDINI, C., TOGNINELLI, A., CARMI, C., ALONGI, M., PETRICCI, E., MASSA, S., CORELLI, F. and BOTTA, M. (2005) Parallel solution-phase and microwave-assisted synthesis of new S-DABO derivatives endowed with subnanomolar anti-HIV-1 activity. JOURNAL OF MEDICINAL CHEMISTRY 48(25), 8000-8008.

106.    MAI, A., ARTICO, M., RAGNO, R., SBARDELLA, G., MASSA, S., MUSIU, C., MURA, M., MARTURANA, F., CADEDDU, A., MAGA, G. and LA COLLA, P. (2005) 5-Alkyl-2-alkylamino-6-(2,6-difluorophenylalkyl)-3,4-dihydropyrimidin-4(3H)-ones, a new series of potent, broad-spectrum non-nucleoside reverse transcriptase inhibitors belonging to the DABO family. BIOORGANIC & MEDICINAL CHEMISTRY 13(6), 2065-2077.

107.    MAGA, G., RAMADAN, K., LOCATELLI, G., SHEVELEV, I., SPADARI, S. and HUBSCHER, U. (2005) DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A. JOURNAL OF BIOLOGICAL CHEMISTRY 280(3), 1971-1981.

108.    MAGA, G., GEMMA, S., FATTORUSSO, C., LOCATELLI, G., BUTINI, S., PERSICO, M., KUKREJA, G., ROMANO, M., CHIASSERINI, L., SAVINI, L., NOVELLINO, E., NACCI, V., SPADARI, S. and CAMPIANI, G. (2005) Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663. BIOCHEMISTRY 44(28), 9637-9644.

109.    MACPHERSON, P., BARONE, F., MAGA, G., MAZZEI, F., KARRAN, P. and BIGNAMI, M. (2005) 8-Oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutS alpha. NUCLEIC ACIDS RESEARCH 33(16), 5094-5105.

110.    LOCATELLI, G., SAVIO, M., FORTI, L., SHEVELEV, I., RAMADAN, K., STIVALA, L., VANNINI, V., HUBSCHER, U., SPADARI, S. and MAGA, G. (2005) Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants. BIOCHEMICAL JOURNAL 389, 259-268.

111.    LOCATELLI, G., DI SANTO, R., CRESPAN, E., COSTI, R., ROUX, A., HUBSCHER, U., SHEVELEV, I., BLANCA, G., VILLANI, G., SPADARI, S. and MAGA, G. (2005) Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells. MOLECULAR PHARMACOLOGY 68(2), 538-550.

112.    FATTORUSSO, C., GEMMA, S., BUTINI, S., HULEATT, P., CATALANOTTI, B., PERSICO, M., DE ANGELIS, M., FIORINI, I., NACCI, V., RAMUNNO, A., RODRIQUEZ, M., GRECO, G., NOVELLINO, E., BERGAMINI, A., MARINI, S., COLETTA, M., MAGA, G., SPADARI, S. and CAMPIANI, G. (2005) Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity. JOURNAL OF MEDICINAL CHEMISTRY 48(23), 7153-7165.

113.    DE MARTINO, G., LA REGINA, G., DI PASQUALI, A., RAGNO, R., BERGAMINI, A., CIAPRINI, C., SINISTRO, A., MAGA, G., CRESPAN, E., ARTICO, M. and SILVESTRI, R. (2005) Novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. A structure-activity relationship investigation. JOURNAL OF MEDICINAL CHEMISTRY 48(13), 4378-4388.

114.    CRESPAN, E., ZANOLI, S., KHANDAZHINSKAYA, A., SHEVELEV, I., JASKO, M., ALEXANDROVA, L., KUKHANOVA, M., BLANCA, G., VILLANI, G., HUBSCHER, U., SPADARI, S. and MAGA, G. (2005) Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases beta and lambda. NUCLEIC ACIDS RESEARCH 33(13), 4117-4127.

115.    CRESPAN, E., LOCATELLI, G., CANCIO, R., HUBSCHER, U., SPADARI, S. and MAGA, G. (2005) Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of Stavudine and zidovudine and its  .... ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 49(1), 342-349.

116.    CANCIO, R., SILVESTRI, R., RAGNO, R., ARTICO, M., DE MARTINO, G., LA REGINA, G., CRESPAN, E., ZANOLI, S., HUBSCHER, U., SPADARI, S. and MAGA, G. (2005) High potency of indolyl aryl sulfone nonnucleoside inhibitors towards drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutants is due to selective targeting of different mechanistic forms of the enzyme. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 49(11), 4546-4554.

117.    BARRECA, M., RAO, A., DE LUCA, L., ZAPPALA, L., MONFORTE, A., MAGA, G., PANNECOUQUE, C., BALZARINI, J., DE CLERCQ, E., CHIMIRRI, A. and MONFORTE, P. (2005) Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT. JOURNAL OF MEDICINAL CHEMISTRY 48(9), 3433-3437.

118.    RAMADAN, K., SHEVELEV, I., MAGA, G. and HUBSCHER, U. (2004) De novo DNA synthesis by human DNA polymerase lambda, DNA polymerase mu and terminal deoxyribonucleotidyl transferase. JOURNAL OF MOLECULAR BIOLOGY 339(2), 395-404.

119.    PAOLUCCI, S., BALDANTI, F., MAGA, G., CANCIO, R., ZAZZI, M., ZAVATTONI, M., CHIESA, A., SPADARI, S. and GERNA, G. (2004) Gln145Met/leu changes in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nucleoside and nonnucleoside analogs and impair virus replication. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 48(12), 4611-4617.

120.    MAGA, G., BLANCA, G., SHEVELEV, I., FROUIN, I., RAMADAN, K., SPADARI, S., VILLANI, G. and HUBSCHER, U. (2004) The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21(/WAF1/CIP1). FASEB JOURNAL 18(12), 1743-+.

121.    MAGA, G. (2004) Management of HIV-1 drug resistance: From novel drugs and targets to clinical benefit assessement - Preface. CURRENT DRUG METABOLISM 5(4).

122.    LOCATELLI, G., CANCIO, R., SPADARI, S. and MAGA, G. (2004) HIV-1 reverse transcriptase inhibitors: Current issues and future perspectives. CURRENT DRUG METABOLISM 5(4), 283-290.

123.    LOCATELLI, G., CAMPIANI, G., CANCIO, R., MORELLI, E., RAMUNNO, A., GERNMA, S., HUBSCHER, U., SPADARI, S. and MAGA, G. (2004) Effects of drug resistance mutations L100I and V106A on the binding of pyrrolobenzoxazepinone nonnucleoside inhibitors to the human immunodeficiency virus type 1 reverse transcriptase catalytic complex. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 48(5), 1570-1580.

124.    CANCIO, R., SPADARI, S. and MAGA, G. (2004) Vif is an auxiliary factor of the HIV-1 reverse transcriptase and facilitates abasic site bypass. BIOCHEMICAL JOURNAL 383, 475-482.

125.    BLANCA, G., VILLANI, G., SHEVELEV, I., RAMADAN, K., SPADARI, S., HUBSCHER, U. and MAGA, G. (2004) Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation. BIOCHEMISTRY 43(36), 11605-11615.

126.    BENARROCH, D., SELISKO, B., LOCATELLI, G., MAGA, G., ROMETTE, J. and CANARD, B. (2004) The RNA helicase, nucleotide 5 '-triphosphatase, and RNA 5 '-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a functional Walker B motif in the helicase catalytic core. VIROLOGY 328(2), 208-218.

127.    SHEVELEV, I., BLANCA, G., VILLANI, G., RAMADAN, K., SPADARI, S., HUBSCHER, U. and MAGA, G. (2003) Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities. NUCLEIC ACIDS RESEARCH 31(23), 6916-6925.

128.    RAMADAN, K., MAGA, G., SHEVELEV, I., VILLANI, G., BLANCO, L. and HUBSCHER, U. (2003) Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: Implications for novel functions. JOURNAL OF MOLECULAR BIOLOGY 328(1), 63-72.

129.    PAOLUCCI, S., BALDANTI, F., TINELLI, M., MAGA, G. and GERNA, G. (2003) Detection of a new HIV-1 reverse transcriptase mutation (Q145M) conferring resistance to nucleoside and non-nucleoside inhibitors in a patient failing highly active antiretroviral therapy. AIDS 17(6), 924-927.

130.    MICCOLI, L., BIARD, D., FROUIN, I., HARPER, F., MAGA, G. and ANGULO, J. (2003) Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner. NUCLEIC ACIDS RESEARCH 31(14), 4162-4175.

131.    MAGA, G. and HUBSCHER, U. (2003) Proliferating cell nuclear antigen (PCNA): a dancer with many partners. JOURNAL OF CELL SCIENCE 116(15), 3051-3060.

132.    FROUIN, I., MONTECUCCO, A., SPADARI, S. and MAGA, G. (2003) DNA replication: a complex matter. EMBO REPORTS 4(7), 666-670.

133.    FROUIN, I., MAGA, G., DENEGRI, M., RIVA, F., SAVIO, M., SPADARI, S., PROSPERI, E. and SCOVASSI, A. (2003) Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21(waf1/cip1) - A dynamic exchange of partners. JOURNAL OF BIOLOGICAL CHEMISTRY 278(41), 39265-39268.

134.    BLANCA, G., SHEVELEV, I., RAMADAN, K., VILLANI, G., SPADARI, S., HUBSCHER, U. and MAGA, G. (2003) Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn++ dependence: a kinetic and thermodynamic study. BIOCHEMISTRY 42(24), 7467-7476.

135.    BLANCA, G., BALDANTI, F., PAOLUCCI, S., SKOBLOV, A., VICTOROVA, L., HUBSCHER, U., GERNA, G., SPADARI, S. and MAGA, G. (2003) Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity. JOURNAL OF BIOLOGICAL CHEMISTRY 278(18), 15469-15472.

136.    BALDANTI, F., PAOLUCCI, S., MAGA, G., LABO, N., HUBSCHER, U., SKOBLOV, A., VICTOROVA, L., SPADARI, S., MINOLI, L. and GERNA, G. (2003) Nevirapine-selected mutations Y181I/C of HIV-1 reverse transcriptase confer cross-resistance to stavudine. AIDS 17(10), 1568-1570.

137.    SALADINO, R., CIAMBECCHINI, U., MAGA, G., MASTROMARINO, P., CONTI, C. and BOTTA, M. (2002) A new and efficient synthesis of substituted 6-[(2 '-dialkylamino)ethyl]pyrimidine and 4-N,N-dialkyl-6-vinyl-cytosine derivatives and evaluation of their anti-rubella activity. BIOORGANIC & MEDICINAL CHEMISTRY 10(7), 2143-2153.

138.    RAMADAN, K., SHEVELEV, I., MAGA, G. and HUBSCHER, U. (2002) DNA polymerase lambda from calf thymus preferentially replicates damaged DNA. JOURNAL OF BIOLOGICAL CHEMISTRY 277(21), 18454-18458.

139.    PASCUCCI, B., MAGA, G., HUBSCHER, U., BJORAS, M., SEEBERG, E., HICKSON, I., VILLANI, G., GIORDANO, C., CELLAI, L. and DOGLIOTTI, E. (2002) Reconstitution of the base excision repair pathway for 7,8-dihydro-8-oxoguanine with purified human proteins. NUCLEIC ACIDS RESEARCH 30(10), 2124-2130.

140.    PAOLUCCI, S., BALDANTI, F., TINELLI, M., LABO, N., CATTANEO, E., MAGA, G. and GERNA, G. (2002) Q145M, a novel HIV-1 reverse transcriptase mutation conferring resistance to nucleoside and non-nucleoside reverse transcriptase inhibitors. ANTIVIRAL THERAPY 7, S46-S46.

141.    MAGA, G., VILLANI, G., RAMADAN, K., SHEVELEV, I., LE GAC, N., BLANCO, L., BLANCA, G., SPADARI, S. and HUBSCHER, U. (2002) Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis. JOURNAL OF BIOLOGICAL CHEMISTRY 277(50), 48434-48440.

142.    MAGA, G. and SPADARI, S. (2002) Combinations against combinations: Associations of anti-HIV 1 reverse transcriptase drugs challenged by constellations of drug resistance mutations. CURRENT DRUG METABOLISM 3(1), 73-95.

143.    MAGA, G., SHEVELEV, I., RAMADAN, K., SPADARI, S. and HUBSCHER, U. (2002) DNA polymerase theta purified from human cells is a high-fidelity enzyme. JOURNAL OF MOLECULAR BIOLOGY 319(2), 359-369.

144.    LOCATELLI, G., SPADARI, S. and MAGA, G. (2002) Hepatitis C virus NS3 ATPase/helicase: An ATP switch regulates the cooperativity among the different substrate binding sites. BIOCHEMISTRY 41(32), 10332-10342.

145.    HUBSCHER, U., MAGA, G. and SPADARI, S. (2002) Eukaryotic DNA polymerases. ANNUAL REVIEW OF BIOCHEMISTRY 71, 133-163.

146.    FROUIN, I., MONTECUCCO, A., BIAMONTI, G., HUBSCHER, U., SPADARI, S. and MAGA, G. (2002) Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins. EMBO JOURNAL 21(10), 2485-2495.

147.    CAMPIANI, G., RAMUNNO, A., MAGA, G., NACCI, V., FATTORUSSO, C., CATALANOTTI, B., MORELLI, E. and NOVELLINO, E. (2002) Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: Past, present, and future perspectives. CURRENT PHARMACEUTICAL DESIGN 8(8), 615-657.

148.    TASARA, T., MAGA, G., HOTTIGER, M. and HUBSCHER, U. (2001) HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other. FEBS LETTERS 507(1), 39-44.

149.    STIVALA, L., SAVIO, M., CARAFOLI, F., PERUCCA, P., BIANCHI, L., MAGA, G., FORTI, L., PAGNONI, U., ALBINI, A., PROSPERI, E. and VANNINI, V. (2001) Specific structural determinants are responsible for the antioxidant activity and the cell cycle effects of resveratrol. JOURNAL OF BIOLOGICAL CHEMISTRY 276(25), 22586-22594.

150.    MAGA, G., VILLANI, G., TILLEMENT, V., STUCKI, M., LOCATELLI, G., FROUIN, I., SPADARI, S. and HUBSCHER, U. (2001) Okazaki fragment processing: Modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(25), 14298-14303.

151.    MAGA, G., RAMUNNO, A., NACCI, V., LOCATELLI, G., SPADARI, S., FIORINI, I., BALDANTI, F., PAOLUCCI, S., ZAVATTONI, M., BERGAMINI, A., GALLETTI, B., MUCK, S., HUBSCHER, U., GIORGI, G., GUISO, G., CACCIA, S. and CAMPIANI, G. (2001) The stereoselective targeting of a specific enzyme-substrate complex is the molecular mechanism for the synergic inhibition of HIV-1 reverse transcriptase by (R)-(-)-PPO464 - A novel generation of nonnucleoside inhibitors. JOURNAL OF BIOLOGICAL CHEMISTRY 276(48), 44653-44662.

152.    MAGA, G., FROUIN, I., SPADARI, S. and HUBSCHER, U. (2001) Replication protein a as a "fidelity clamp" for DNA polymerase alpha. JOURNAL OF BIOLOGICAL CHEMISTRY 276(21), 18235-18242.

153.    MAGA, G., HUBSCHER, U., PREGNOLATO, M., UBIALI, D., GOSSELIN, G. and SPADARI, S. (2001) Potentiation of inhibition of wild-type and mutant human immunodeficiency virus type 1 reverse transcriptases by combinations of nonnucleoside inhibitors and D- and L-(beta)-dideoxynucleoside triphosphate analogs. Antimicrobial Agents and Chemotherapy 45(4), 1192-1200.

154.    LOCATELLI, G., GOSSELIN, G., SPADARI, S. and MAGA, G. (2001) Hepatitis C virus NS3NTPase/helicase: Different stereoselectivity in nucleoside triphosphate utilisation suggests that NTPase and helicase activities are coupled by a nucleotide-dependent rate limiting step. JOURNAL OF MOLECULAR BIOLOGY 313(4), 683-694.

155.    CAMPIANI, G., AIELLO, F., FABBRINI, M., MORELLI, E., RAMUNNO, A., ARMAROLI, S., NACCI, V., GAROFALO, A., GRECO, G., NOVELLINO, E., MAGA, G., SPADARI, S., BERGAMINI, A., VENTURA, L., BONGIOVANNI, B., CAPOZZI, M., BOLACCHI, F., MARINI, S., COLETTA, M., GUISO, G. and CACCIA, S. (2001) Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent. JOURNAL OF MEDICINAL CHEMISTRY 44(3), 305-315.

156.    BOTTA, M., CORELLI, F., MAGA, G., MANETTI, F., RENZULLI, M. and SPADARI, S. (2001) Research on anti-HIV-1 agents. Part 2: Solid-phase synthesis, biological evaluation and molecular modeling studies of 2,5,6-trisubstituted-4(3H)-pyrimidinones targeting HIV-1 reverse transcriptase. TETRAHEDRON 57(39), 8357-8367.

157.    MAGA, G., UBIALI, D., SALVETTI, R., PREGNOLATO, M. and SPADARI, S. (2000) Selective interaction of the human immunodeficiency virus type 1 reverse transcriptase nonnucleoside inhibitor efavirenz and its thio-substituted analog with different enzyme-substrate complexes. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 44(5), 1186-1194.

158.    MAGA, G., STUCKI, M., SPADARI, S. and HUBSCHER, U. (2000) DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading. JOURNAL OF MOLECULAR BIOLOGY 295(4), 791-801.

159.    CAMPIANI, G., FABBRINI, M., MORELLI, E., NACCI, V., GRECO, G., NOVELLINO, E., MAGA, G., SPADARI, S., BERGAMINI, A., FAGGIOLI, E., UCCELLA, I., BOLACCHI, F., MARINI, S., COLETTA, M., FRACASSO, C. and CACCIA, S. (2000) Non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis and biological evaluation of novel quinoxalinylethylpyridylthioureas as potent antiviral agents. ANTIVIRAL CHEMISTRY & CHEMOTHERAPY 11(2), 141-155.

160.    MARX, A., SPICHTY, M., AMACKER, M., SCHWITTER, U., HUBSCHER, U., BICKLE, T., MAGA, G. and GIESE, B. (1999) Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides. CHEMISTRY & BIOLOGY 6(2), 111-116.

161.    MAGA, G., JONSSON, Z., STUCKI, M., SPADARI, S. and HUBSCHER, U. (1999) Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis. JOURNAL OF MOLECULAR BIOLOGY 285(1), 259-267.

162.    MAGA, G., AMACKER, M., HUBSCHER, U., GOSSELIN, G., IMBACH, J., MATHE, C., FARAJ, A., SOMMADOSSI, J. and SPADARI, S. (1999) Structural determinants of HIV-1 reverse transcriptase stereoselectivity towards (beta)-L-deoxy- and dideoxy pyrimidine nucleoside triphosphates: Molecular basis for the combination of L-dideoxynucleoside analogs with nonnucleoside inhibitors in anti ... XIII International Round Table Conference on Nucleosides, Nucleotides and their Biological Applications. Vol. 18, 795-805.

163.    MAGA, G., AMACKER, M., HUBSCHER, U., GOSSELIN, G., IMBACH, J., MATHE, C., FARAJ, A., SOMMADOSSI, J. and SPADARI, S. (1999) Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3 '-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs. NUCLEIC ACIDS RESEARCH 27(4), 972-978.

164.    KELLER, R., MOSSI, R., MAGA, G., WELLINGER, R., HUBSCHER, U. and SOGO, J. (1999) Electron microscopic analysis reveals that replication factor C is sequestered by single-stranded DNA. NUCLEIC ACIDS RESEARCH 27(17), 3433-3437.

165.    CAMPIANI, G., MORELLI, E., FABBRINI, M., NACCI, V., GRECO, G., NOVELLINO, E., RAMUNNO, A., MAGA, G., SPADARI, S., CALIENDO, G., BERGAMINI, A., FAGGIOLI, E., UCCELLA, I., BOLACCHI, F., MARINI, S., COLETTA, M., NACCA, A. and CACCIA, S. (1999) Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: Further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity. JOURNAL OF MEDICINAL CHEMISTRY 42(21), 4462-4470.

166.    SPADARI, S., MAGA, G., VERRI, A. and FOCHER, F. (1998) Molecular basis for the antiviral and anticancer activities of unnatural L-beta-nucleosides. Expert Opin Investig Drugs 7(8), 1285-300.

167.    SCHURTENBERGER, P., EGELHAAF, S., HINDGES, R., MAGA, G., JONSSON, Z., MAY, R., GLATTER, O. and HUBSCHER, U. (1998) The solution structure of functionally active human proliferating cell nuclear antigen determined by small-angle neutron scattering. JOURNAL OF MOLECULAR BIOLOGY 275(1), 123-132.

168.    PERDERISET, M., MAGA, G., PIARD, K., FRANCESCONI, S., TRATNER, I., HUBSCHER, U. and BALDACCI, G. (1998) Mutant DNA polymerase delta from thermosensitive Schizosaccharomyces pombe strains display reduced stimulation by proliferating cell nuclear antigen. BIOCHEMICAL JOURNAL 335, 581-588.

169.    NIZI, E., BOTTA, M., CORELLI, F., MANETTI, F., MESSINA, F. and MAGA, G. (1998) Solid phase synthesis of 2,6-disubstituted-4(3H)-pyrimidinones targeting HIV-1 reverse transcriptase. TETRAHEDRON LETTERS 39(20), 3307-3310.

170.    MAGA, G., MOSSI, R., FISCHER, R., BERCHTOLD, M. and HUBSCHER, U. (1997) Phosphorylation of the PCNA binding domain of the large subunit of replication factor C by Ca2+/calmodulin-dependent protein kinase inhibits DNA synthesis. BIOCHEMISTRY 36(18), 5300-5310.

171.    MAGA, G., AMACKER, M., RUEL, N., HUBSCHER, U. and SPADARI, S. (1997) Resistance to Nevirapine of HIV-1 reverse transcriptase mutants: Loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions. JOURNAL OF MOLECULAR BIOLOGY 274(5), 738-747.

172.    KROTH, H., HORLACHER, J., AMACKER, M., MAGA, G., HUBSCHER, U., FRIEDBERG, T., OESCH, F. and SEIDEL, A. (1997) Influence of trans-N-6-deoxyadenosine adducts of various polycyclic aromatic hydrocarbon anti-diol epoxides placed at codon 61 of partial human Ha-ras protooncogene sequences on the action of E-coli Pol I, HIV-1 RT and calf thymus Pol beta. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 355(4), 632-632.

173.    KRIKORIAN, D., PARUSHEV, S., TARPANOV, V., MECHKAROVA, P., MIKHOVA, B., BOTTA, M., CORELLI, F., MAGA, G. and SPADARI, S. (1997) Synthesis and biological evaluation of imidazo[1,2-d][1,4]benzodiazepines and related compounds as potential anti-HIV-1 agents. MEDICINAL CHEMISTRY RESEARCH 7(9), 546-556.

174.    MAGA, G. and HUBSCHER, U. (1996) DNA replication machinery: Functional characterization of a complex containing DNA polymerase alpha, DNA polymerase delta, and replication factor C suggests an asymmetric DNA polymerase dimer. BIOCHEMISTRY 35(18), 5764-5777.

175.    FOTEDAR, R., MOSSI, R., FITZGERALD, P., ROUSSELLE, T., MAGA, G., BRICKNER, H., MESSIER, H., KASIBHATLA, S., HUBSCHER, U. and FOTEDAR, A. (1996) A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells. EMBO JOURNAL 15(16), 4423-4433.

176.    XU, H., MAGA, G., FOCHER, F., SMITH, E., SPADARI, S., GAMBINO, J. and WRIGHT, G. (1995) SYNTHESIS, PROPERTIES, AND PHARMACOKINETIC STUDIES OF N-2-PHENYLGUANINE DERIVATIVES AS INHIBITORS OF HERPES-SIMPLEX VIRUS THYMIDINE KINASES. JOURNAL OF MEDICINAL CHEMISTRY 38(1), 49-57.

177.    SPADARI, S., MAGA, G., VERRI, A., BENDISCIOLI, A., TONDELLI, L., CAPOBIANCO, M., COLONNA, F., GARBESI, A. and FOCHER, F. (1995) Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: Molecular basis for the antiviral activity of unnatural L-beta-nucleosides. BIOCHIMIE 77(11), 861-867.

178.    SPADARI, S., CIARROCCHI, G., FOCHER, F., VERRI, A., MAGA, G., ARCAMONE, F., IAFRATE, E., MANZINI, S., GARBESI, A. and TONDELLI, L. (1995) 5-IODO-2'-DEOXY-L-URIDINE AND (E)-5-(2-BROMOVINYL)-2'-DEOXY-L-URIDINE - SELECTIVE PHOSPHORYLATION BY HERPES-SIMPLEX VIRUS TYPE-1 THYMIDINE KINASE, ANTIHERPETIC ACTIVITY, AND CYTOTOXICITY STUDIES. MOLECULAR PHARMACOLOGY 47(6), 1231-1238.

179.    MAGA, G. and HUBSCHER, U. (1995) DNA-POLYMERASE-EPSILON INTERACTS WITH PROLIFERATING CELL NUCLEAR ANTIGEN IN PRIMER RECOGNITION AND ELONGATION. BIOCHEMISTRY 34(3), 891-901.

180.    HOFFMANN, J., PILLAIRE, M., MAGA, G., PODUST, V., HUBSCHER, U. and VILLANI, G. (1995) DNA-POLYMERASE-BETA BYPASSES IN-VITRO A SINGLE D(GPG)-CISPLATIN ADDUCT PLACED ON CODON-13 OF THE HRAS GENE. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 92(12), 5356-5360.

181.    HOFFMANN, J., PILLAIRE, M., MAGA, G., PODUST, V., HUBSCHER, U. and VILLANI, G. (1995) DNA POLYMERASE-B BYPASSES A SINGLE D(GPG)-CISPLATIN ADDUCT. JOURNAL OF CELLULAR BIOCHEMISTRY, 307-307.

182.    FOCHER, F., MAGA, G., BENDISCIOLI, A., CAPOBIANCO, W., COLONNA, F., GARBESI, A. and SPADARI, S. (1995) STEREOSPECIFICITY OF HUMAN DNA-POLYMERASE-ALPHA, DNA-POLYMERASE-BETA, DNA-POLYMERASE-GAMMA, DNA-POLYMERASE-DELTA AND DNA-POLYMERASE-EPSILON, HIV-REVERSE TRANSCRIPTASE, HSV-1 DNA-POLYMERASE, CALF THYMUS TERMINAL TRANSFERASE AND ESCHERICHIA-COLI DNA-PO ... NUCLEIC ACIDS RESEARCH 23(15), 2840-2847.

183.    VERRI, A., MAGA, G., SPADARI, S., PONTI, W., STROSSELLI, S., BONIZZI, L., ROCCHI, M., POLI, G. and FOCHER, F. (1994) Aphidicolin inhibits in vitro the activity of pseudorabies virus (PRV) DNA polymerase and in vivo the viral proliferation. In Vivo (Attiki) 8(6), 1041-1046.

184.    MAGA, G., SPADARI, S., WRIGHT, G. and FOCHER, F. (1994) IDENTIFICATION, PARTIAL-PURIFICATION AND INHIBITION BY GUANINE ANALOGS OF A NOVEL ENZYMATIC-ACTIVITY WHICH PHOSPHORYLATES GUANOSINE TO GMP IN THE PROTOZOAN PARASITE EIMERIA-TENELLA. BIOCHEMICAL JOURNAL 298, 289-294.

185.    MAGA, G., FOCHER, F., WRIGHT, G., CAPOBIANCO, M., GARBESI, A., BENDISCIOLI, A. and SPADARI, S. (1994) KINETIC-STUDIES WITH N-2-PHENYLGUANINES AND WITH L-THYMIDINE INDICATE THAT HERPES-SIMPLEX VIRUS TYPE-1 THYMIDINE KINASE AND THYMIDYLATE KINASE SHARE A COMMON ACTIVE-SITE. BIOCHEMICAL JOURNAL 302, 279-282.

186.    CASTAGNA, R., MAGA, G., PERENZIN, M., HEUN, M. and SALAMINI, F. (1994) RFLP BASED GENETIC-RELATIONSHIPS OF EINKORN WHEATS. THEORETICAL AND APPLIED GENETICS 88(6-7), 818-823.

187.    MAGA, G., VERRI, A., BONIZZI, L., PONTI, W., POLI, G., GARBESI, A., NICCOLAI, D., SPADARI, S. and FOCHER, F. (1993) LACK OF STEREOSPECIFICITY OF SUID PSEUDORABIES VIRUS THYMIDINE KINASE. BIOCHEMICAL JOURNAL 294, 381-385.

188.    SPADARI, S., MAGA, G., FOCHER, F., CIARROCCHI, G., MANSERVIGI, R., ARCAMONE, F., CAPOBIANCO, M., CARCURO, A., COLONNA, F., IOTTI, S. and GARBESI, A. (1992) L-THYMIDINE IS PHOSPHORYLATED BY HERPES-SIMPLEX VIRUS TYPE-1 THYMIDINE KINASE AND INHIBITS VIRAL GROWTH. JOURNAL OF MEDICINAL CHEMISTRY 35(22), 4214-4220.

189.    MAZZARELLO, P., VERRI, A., MONDELLO, C., COLOMBO, S., MAGA, G., SPADARI, S. and FOCHER, F. (1992) ENZYMES OF DNA METABOLISM IN A PATIENT WITH THE WIEDEMANN-RAUTENSTRAUCH PROGEROID SYNDROME. CONF ON AGING AND CELLULAR DEFENSE MECHANISMS. Vol. 663, 440-441.

190.    GAMBINO, J., FOCHER, F., HILDEBRAND, C., MAGA, G., NOONAN, T., SPADARI, S. and WRIGHT, G. (1992) QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS OF N-2-PHENYLGUANINES AS INHIBITORS OF HERPES-SIMPLEX VIRUS THYMIDINE KINASES. JOURNAL OF MEDICINAL CHEMISTRY 35(16), 2979-2983.

191.    FOCHER, F., VERRI, A., MAGA, G., SPADARI, S. and HUBSCHER, U. (1990) EFFECT OF DIVALENT AND MONOVALENT CATIONS ON CALF THYMUS PCNA-INDEPENDENT DNA POLYMERASE-DELTA AND ITS 3'-]5' EXONUCLEASE. FEBS LETTERS 259(2), 349-352.

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